DOI: 10.1002/uog.22125
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Tamara Stampalija
1
,
Jim Thornton
2
,
Neil Marlow
3
et al.
Abstract: ObjectivesTo explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction.MethodsThis was a prospective cohort study of singleton pregnancies at risk of fetal growth restriction at 32 + 0 to 36 + 6 weeks of gestation, enrolled in 33 European centers between 2017 and 2018, in which umbilical and fetal MCA Doppler velocimetry was performed. Pregnancies were considered at risk of fetal growth r… Show more
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Cited by 59 publications
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“…In our opinion, the relevance of the current discussion on UCR vs CPR should be focused on the clinical applicability of these parameters. Our data, and several recent publications, show that neither parameter is a particularly good predictor of short-and long-term infant outcomes in preterm or term pregnancies 2,[7][8][9][10] . It has to be acknowledged that the data are based on observational studies, mostly retrospective, hence, a possible association of either ratio with adverse outcome could be negated by the obstetric management used in the study.…”
Section: Replysupporting confidence: 64%
No abstract
“…In our opinion, the relevance of the current discussion on UCR vs CPR should be focused on the clinical applicability of these parameters. Our data, and several recent publications, show that neither parameter is a particularly good predictor of short-and long-term infant outcomes in preterm or term pregnancies 2,[7][8][9][10] . It has to be acknowledged that the data are based on observational studies, mostly retrospective, hence, a possible association of either ratio with adverse outcome could be negated by the obstetric management used in the study.…”
Section: Replysupporting confidence: 64%
No abstract
“…Several studies have found an association between MCA vasodilatation (i.e. reduction in MCA-PI) or the alteration of its ratio with UA-PI and poorer perinatal outcome 86 , including stillbirth 39 , higher risk of Cesarean delivery [87][88][89] , and increased risk of abnormal neurodevelopment at birth 90 and at 2 years of age 91 . The rationale for using the ratios of MCA-PI and UA-PI (CPR and UCR) is that they can identify subtle changes between placental and cerebral blood-flow perfusion that may not be appreciated by evaluation of a single parameter.…”
Section: Late-onset Fetal Growth Restrictionmentioning confidence: 99%
Lees
1
,
Stampalija
2
,
Baschat
3
et al. 2020
Self Cite
ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restrictionClinical Standards CommitteeThe International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, and high-quality teaching and research related to diagnostic imaging in women's healthcare. The ISUOG Clinical Standards Committee (CSC) has a remit to develop Practice Guidelines and Consensus Statements as educational recommendations that provide healthcare practitioners with a consensus-based approach, from experts, for diagnostic imaging. They are intended to reflect what is considered by ISUOG to be the best practice at the time at which they are issued. Although ISUOG has made every effort to ensure that Guidelines are accurate when issued, neither the Society nor any of its employees or members accepts any liability for the consequences of any inaccurate or misleading data, opinions or statements issued by the CSC. The ISUOG CSC documents are not intended to establish a legal standard of care, because interpretation of the evidence that underpins the Guidelines may be influenced by individual circumstances, local protocol and available resources. Approved Guidelines can be distributed freely with the permission of ISUOG (
“…CPR has also been studied for its utility in predicting adverse outcomes and guiding delivery timing in late FGR [27][28][29][30][31] . Recently, a prospective multicenter observational feasibility study, involving 856 pregnancies with late FGR, was undertaken as part of the design process for the TRUFFLE-2 randomized trial for determining arterial Doppler thresholds that are most strongly associated with adverse outcome and optimal timing for delivery 16 . The study showed that the first Doppler observation of MCA pulsatility index < 5 th percentile and umbilicocerebral ratio Z-score above gestational-age-specific thresholds had the highest relative risks for composite adverse outcome, although gestational age at delivery and birth-weight Z-score showed a stronger association 16 .…”
Section: Middle Cerebral Artery Dopplermentioning confidence: 99%
Abuhamad
1
,
Martins
2
,
Biggio
3
2021
No abstract
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